Job Description

Job Description

Who we are:

miRecule, Inc. is a rapidly growing biotechnology start-up focused on the development of RNA therapeutics to treat a variety of diseases. miRecule’s DREAmiRTM genomics-based discovery platform is designed to create best-in-class RNA therapies, identifying critical RNA targets for drug development in specific subsets of patients that would benefit from treatment. We then create proprietary chemically modified RNA therapeutics with improved pharmacology, while utilizing antibodies for targeted delivery to the diseased tissue.

Senior RA – RNA Therapeutics Development:

This is a lab-based research role focused on performing analytical chemistry and manufacturing support for miRecule’s Antibody RNA conjugates (ARCs), as well as mechanism of action and pharmacology studies on the muscle delivery program.

Essential Duties and Responsibilities:

· Planning and execution of in vitro cell culture assays, including cellular toxicity, viability assays, immunoassays, and cell-based screening as well as processing and analyses of tissue samples.

· Synthesis, purification and validation of antibody RNA conjugates using HPLC, FPLC, plate and UV based assays.

· Generation of clear oral and written communications presenting analysis of experimental data, interpretation of results, and recommendation of next steps.

· Detailed recording of experimental results in company electronic lab notebook (ELN).

· Manage relationships with external service providers.

· Collaborate cross-functionally as needed across the miRecule business, operations, and scientific teams.

· Perform other duties as assigned.

Qualifications:

Education and Experience:

· M.S. (or equivalent degree) in Biochemistry, Molecular Biology, Cell Biology, Neurobiology, pharmaceutical sciences, or related disciplines and 2 - 4 years of lab-based experience

Or B.S. degree in Biochemistry, Molecular Biology, Cell Biology, Organic Chemistry, pharmaceutical sciences, or related disciplines and 5+ years of relevant experience.

Essential Skills:

· Hands on experience with conjugation chemistries commonly used in ADCs or ARCs.

· Experience handling various antibody formats including mAb, Fab, scFv and VHH.

· Competency in protein purification techniques such as SEC, IEX, dialysis, TFF or UF/DF.

· Knowledge of immunoassays such as ELISA and western blot to validate antibody/ARC activity.

· Aseptic cell culture skill and expertise in culturing primary cells and/or cell lines.

· Delivery of nucleic acids to in vitro and in vivo models.

· Molecular biology techniques to evaluate on-target and off-target activity of RNA related compounds. Processing cells and tissues, including skeletal muscles, for isolating RNA and proteins.

· Designing, executing and interpreting qPCR studies.

· Affinity to learn about novel technologies and willingness to contribute to the development.

· Ability to adapt and thrive in a fast-paced, innovative environment.

Desired Skills:

· Direct experience with evaluating the PK and efficacy of RNA therapeutics including molecular and protein bioanalytic across multiple tissues (biodistribution) to support in vivo POC or toxicology studies.

· Fundamental understanding of chemical modifications utilized in oligonucleotide therapies and their impact on potency and toxicity.

· Experience in presenting data at internal and external meetings with our external partners and CROs to execute on the discovery and development of our lead therapeutic product.

· Industry experience with knowledge on nucleic acid therapeutics drug development process

Our culture

At miRecule, we have strived to cultivate a mission-centered culture, enabling the creation of high-quality RNA therapies that can truly change the lives of patients. miRecule employees live the tenets of scientific rigor, teamwork, and mutual respect, allowing us to grow cohesively as a team and help each other to learn and succeed in our pursuit of this important mission. We seek individuals to join our team who resonate with this philosophy both professionally and personally.

Equal Opportunity Employer

All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, age, disability, veteran status, or any other classification protected by federal, state, or local law. If you are an individual with a disability and need accommodation to complete the application, please email us at  dharrer@mirecule.com

Direct Applicants Only – No Agencies Please

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